Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetInduce apoptosis

Product does not compete with ATP.

General description

A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca²⁺ from intracellular stores. Downregulates the activity of serine/threonine protein kinase casein kinase II in HT29 cells.

A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca²⁺ from intracellular stores. Reduces histamine-induced calcium mobilization in C6 glioma cells. Down-regulates the activity of the serine/threonine protein kinase casein kinase II in HT29 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ou, H.C., et al. 1997. Neuroreport 8, 1375.Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.Krupitza, G., et al. 1995. Carcinogenesis16, 1199.Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun.195, 31.Hague, A., et al. 1993. Int. J. Cancer55, 498.

Packaging

250 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Irritant (B)